Shaktar Donetsk host Arsenal in Group H at Donbass Arena. The English side defeated the Ukrainian team 5-1, and both teams are in the top half of their table.
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Goals for Arsenal in the previous match up came from: Alex Song, Samir Nasri, Cesc Fabregas, Jack Wilshire and Marouane Chamakh. Former Arsenal striker Eduardo scored the only goal for Shaktar.
Arsenal will be missing injured captain Fabregas, and key midfielders Song, Arshavin and Denilson are also doubtful for the tie. Manager Arsene Wenger can afford to rest his key players now his side look all but assured of progressing to the next round thanks to their safety margin of points.